Publications 2010-2014

Pubs 2014

Liu J, Ma DW. The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer. Nutrients. 2014 Nov 18;6(11):5184-223. doi: 10.3390/nu6115184. PMID: 25412153.

Monk JM, Turk HF, Liddle DM, De Boer AA, Power KA, Ma DW, Robinson LE. N-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer.  Nutrients. 2014 Oct 30;6(11):4760-93. doi: 10.3390/nu6114760.

Leslie MA, Abdelmagid SA, Perez K, Muller WJ, Ma DW. Mammary tumour development is dose-dependently inhibited by n-3 polyunsaturated fatty acids in the MMTV-neu(ndl)-YD5 transgenic mouse model. Lipids Health Dis. 2014 Jun 11;13(1):96. PMID: 24916956.

Anderson BM, Maclennan MB, Hillyer LM, Ma DW. Lifelong exposure to n-3 PUFA affects pubertal mammary gland development. Appl Physiol Nutr Metab. 2014 Jun;39(6):699-706. doi: 10.1139/apnm-2013-0365. PMID: 24758708

Proceedings from the 2013 Canadian Nutrition Society Conference.  Holub B, Mutch DM, Pierce GN, Rodriguez-Leyva D, Aliani M, Innis S, Yan W, Lamarche B, Couture P, Ma DW Appl Physiol Nutr Metab. 2014 Jul;39(7):754-62. doi: 10.1139/apnm-2013-0418. Epub 2014 Jan 23.  PMID: 24749841

Clarke SE, Kang JX, Ma DW. The iFat1 Transgene Permits Conditional Endogenous n-3 PUFA Enrichment both in vitro and in vivo. Transgenic Res. 2014 Jun;23(3):489-501. doi: 10.1007/s11248-014-9788-x. Epub 2014 Mar 13. PMID: 24622775

Monteiro J, Leslie M, Moghadasian MH, Arendt BM, Allard JP, Ma DW. The role of n-6 and n-3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease. Food Funct. 2014 Feb 26;5(3):426-35. doi: 10.1039/c3fo60551e. PMID: 24496399.

Teri S, Acai A, Griffith D, Mahmoud Q, Ma DW, Newton G. Student use and pedagogical impact of a mobile learning application. Biochem Mol Biol Educ. 2014 Mar;42(2):121-35. doi: 10.1002/bmb.20771. PMID: 24375862

Perreault M, Roke K, Badawi A, Nielsen DE, Abdelmagid SA, El-Sohemy A, Ma DW, Mutch DM. Plasma Levels of 14:0, 16:0, 16:1n-7, and 20:3n-6 are Positively Associated, but 18:0 and 18:2n-6 are Inversely Associated with Markers of Inflammation in Young Healthy Adults. Lipids. 2014 Mar;49(3):255-63. doi: 10.1007/s11745-013-3874-3. PMID: 24338596

Pubs 2013

Lau BY, Cohen DJ, Ward WE, Ma DW. Investigating the role of polyunsaturated Fatty acids in bone development using animal models. Molecules. 2013 Nov 15;18(11):14203-27. doi: 10.3390/molecules181114203. PMID: 24248147

D. Kelton, C. Lysecki, H. Aukema, B. Anderson, J.X. Kang, Ma DW. Endogenous synthesis of n-3 PUFA modifies fatty acid composition of kidney phospholipids and eicosanoid levels in the fat-1 mouse., Prostaglandins Leukot Essent Fatty Acids. 2013 Aug 13. pii: S0952-3278(13)00159-2. doi: 10.1016/j.plefa.2013.08.002. PMID: 23994161

Abdelmagid SA, Clarke SE, Wong J, Roke K, Nielsen D, Badawi A, El-Sohemy A, Mutch DM, Ma DW. Plasma concentration of cis9trans11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study. Nutr Metab (Lond). 2013 Jul 18;10(1):50.  PMID: 23866021

Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RP. Unesterified docosahexaenoic acid is protective in neuroinflammation. J Neurochem. 2013 Aug 6. doi: 10.1111/jnc.12392. PMID: 23919613

Roke K, Ralston JC, Abdelmagid S, Nielsen DE, Badawi A, El-Sohemy A, David WL Ma, Mutch DM. Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults. Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):257-63. doi: 10.1016/j.plefa.2013.06.003. Epub 2013 Jul 16. PMID: 23867726

Ralston JC, Zulyniak MA, Nielsen DE, Clarke S, Badawi A, El-Sohemy A, David WL Ma, Mutch DM. Ethnic- and sex-specific associations between plasma fatty acids and markers of insulin resistance in healthy young adults. Nutr Metab (Lond). 2013 Jun 17;10(1):42. doi: 10.1186/1743-7075-10-42. PMID: 23773230.

Monteiro J, Askarian F, Nakamura MT, Moghadasian MH, David WL Ma. Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. Can J Physiol Pharmacol. 2013 Jun;91(6):469-79. doi: 10.1139/cjpp-2012-0308. Epub 2012 Dec 13. PMID: 23746194

Reza López SA, Poon AN, Szeto IM, David WL Ma, Anderson GH. High multivitamin intakes during pregnancy and postweaning obesogenic diets interact to affect the relationship between expression of PPAR genes and glucose regulation in the offspring. J Nutr Biochem. 2013 May;24(5):877-81. doi: 10.1016/j.jnutbio.2012.06.001. Epub 2012 Aug 20. PMID: 22917842

Arendt BM, David WL Ma, Simons B, Noureldin SA, Therapondos G, Guindi M, Sherman M, Allard JP. Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. Appl Physiol Nutr Metab. 2013 Mar;38(3):334-40. doi: 10.1139/apnm-2012-0261. Epub 2012 Oct 15. PMID: 23537027

Azordegan N, Fraser V, Le K, Hillyer LM, David WL Ma, Fischer G, Moghadasian MH. Carcinogenesis alters fatty acid profile in breast tissue. Mol Cell Biochem. 2013 Feb;374(1-2):223-32. doi: 10.1007/s11010-012-1523-4. Epub 2012 Nov 23. PMID: 23180247

Maclennan MB, Clarke SE, Perez K, Wood GA, Muller WJ, Kang JX, David WL Ma. Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids. J Nutr Biochem. 2013 Jan;24(1):388-95. doi: 10.1016/j.jnutbio.2012.08.002. Epub 2012 Sep 29. PMID: 23026490


Pubs 2012

Q. Wang, X. Yang, S. Leonard, T. Archbold, J. A. Sullivan, A. M. Duncan, David WL Ma, B. Bizimungu, A. Murphy, J. K. Htoo, and M. Z. Fan. Responses of dietary ileal amino acid digestibility to consumption of different cultivars of potatoes and conventional fibers in pigs fed a high-fat basal diet. J Anim Sci. 2012 Dec;90 Suppl 4:356-8. doi: 10.2527/jas.53807. PMID: 23365378

Zulyniak MA, Ralston JC, Tucker AJ, Mackay KA, Hillyer LM, McNicholas PD, Graham TE, Robinson LE, Duncan AM, David WL Ma, Mutch DM. Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men. Appl Physiol Nutr Metab. 2012 Oct;37(5):1003-7. doi: 10.1139/h2012-081. Epub 2012 Jun 21. PMID: 22720879

Monteiro J, Li FJ, Maclennan M, Rabalski A, Moghadasian MH, Nakamura MT, David WL Ma. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. Lipids Health Dis. 2012 May 29;11:60. doi: 10.1186/1476-511X-11-60. PMI: 22642787

Stryjecki C, Roke K, Clarke S, Nielsen D, Badawi A, El-Sohemy A, David WL Ma, Mutch DM. Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation. Mol Genet Metab. 2012 Mar;105(3):421-7. doi: 10.1016/j.ymgme.2011.12.003. Epub 2011 Dec 13. PMID: 22209225

Pubs 2011

Mira B. MacLennan, Breanne M. Andersonand David WL Ma.  Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research. Nutrients. 2011 Nov;3(11):929-36. Epub 2011 Oct 25. PMID: 22254086

Dyck MC, David WL Ma, and Meckling KA. The anticancer effects of Vitamin D and omega-3 PUFAs in combination via cod-liver oil: One plus one may equal more than two. Med Hypotheses. 2011 May 30. [Epub ahead of print] PMID: 21632182

Arendt BM, Mohammed SS, David WL Ma, Aghdassi E, Salit IE, Wong DK, Guindi M, Sherman M, Heathcote EJ, Allard JP.  Non-Alcoholic Fatty Liver Disease in HIV Infection Associated with Altered Hepatic Fatty Acid Composition. Curr HIV Res. 2011 Mar 24. PMID: 21434863

Ellie Aghassi, David WL Ma, Shannon Clarke, Lyn Hillyerand Paul Fortin. Alteration in Circulating Fatty Acid Composition in Patients with Systemic Lupus Erythematosus: A Pilot Study. (Invited paper), JPEN J Parenter Enteral Nutr. 2011 Mar-Apr;35(2):198-208. PMID: 21378249

Diana M Merino, Holly Johnston, Shannon Clarke, Ahmed El-Sohemy, David WL Ma, and David M Mutch. Polymorphisms in fatty acid desaturase (FADS) genes affect n-3 and n-6 fatty acid metabolism in a multiethnic population of young healthy adults. Molecular Genetics and Metabolism. 2011 Feb 23. PMID: 21414826

Justine Tichinsky, David WL Ma and Lindsay E. Robinson. Adiponectin. Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocyte. Obesity (Silver Spring). 2011 Feb;19(2):262-8. PMID: 20814411

Pubs 2010

Mira MacLennan and David WL Ma. Role of dietary fatty acids in mammary gland development and breast cancer. Breast Cancer Research, 2010 Oct 26;12(5):211. PMID: 21067551

Brennan K. Smith, Graham P. Holloway, Sandra Reza-Lopez, Stan Jeram, Jing X. Kang and David WL Ma. A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved insulin sensitivity. Applied Physiology Nutrition and Metabolism, 2010 Oct;35(5):699-706. PMID: 20962926

Beatrice Lau, Wendy E. Ward, Jing X. Kang and David WL Ma.  Fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids., APNM.  2010,35(4):447-455. PMID: 20725110

Diana M Merino, David WL Ma and David M Mutch. Genetic variation in lipid desaturases and its impact on the development of human disease. Lipids in Health and Disease 2010, 9:63 (18 June 2010)  PMID: 20565855

Pedro Huot, Baisahki Sarkar, David WL Ma. CLA alters caveolae phospholipid fatty acid composition and decreases caveolin-1 expression in MCF-7 breast cancer cells. Nutrition Research. 2010 Mar;30(3):179-85. PMID: 20417878

Cynthia Boudrault, Richard P. Bazinet, Jing X. Kang and David WL Ma. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010 Mar;56(4):585-9. PMID: 20064570.

Sarah K Orr, Jasmin Tong, Jing X. Kang, David WL Ma, and Richard P Bazinet.. The Fat-1 Mouse has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding. Neurochem Res. 2010 May;35(5):811-9. PMID: 20177777